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Twenty-four patients (14%) developedthiopurine-related adverse drug reactions, revealing a significant association between GST-M1-null genotype (P=0.05), older age (P=0.016) and active smoking status (P=0.043) andserious adverse events. Because randomchance determines the assignment of subjects to experimental and control groups (and,therefore, the distribution of extraneous variables to experimental and control groups), it ispossible occasionally for the two groups to differ on some variables. (2006) Aerobic exer-cise training increases brain volume in aging humans.

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